1. feeling isolated, estranged, or disconnected from others or from society
2. having been made hostile or unfriendly toward someone or something

Examples

• Many teenagers feel alienated from their parents during adolescence.
• The new employee felt alienated by his coworkers’ unfriendly behavior.
• She became alienated from her former friends after the argument.
• The policy changes alienated many longtime supporters of the organization.
• He felt alienated in the big city where nobody knew his name.
• The harsh criticism alienated potential allies from their cause.