noun
- A synthetic compound that inhibits the enzyme dihydrofolate reductase, used as an anticancer and immunosuppressive drug.
Usage: technical; medical; chemistry
Examples
- Aminopterin was one of the first drugs used to treat acute leukemia in children.
- The drug aminopterin works by blocking folate metabolism in rapidly dividing cells.
- Researchers studied aminopterin's effects on tumor growth in laboratory models.
- Aminopterin is structurally similar to methotrexate but has different clinical applications.
- The discovery of aminopterin marked an important milestone in cancer chemotherapy.