noun
- Plural of aminopterin; synthetic compounds that inhibit dihydrofolate reductase and are used in cancer chemotherapy and immunosuppression.
Usage: technical; medical/pharmaceutical
Examples
- Aminopterins are used in combination with other drugs to treat certain types of leukemia.
- The mechanism of action of aminopterins involves blocking folate metabolism in rapidly dividing cells.
- Researchers studied the effects of aminopterins on tumor growth in laboratory models.
- Aminopterins have been employed in immunosuppressive protocols for organ transplant patients.