1. superlative form of bitter: having the most sharp, unpleasant taste
2. superlative form of bitter: showing the most anger, hatred, or resentment
3. superlative form of bitter: causing the most pain or distress

Examples

• This is the bitterest medicine I’ve ever tasted.
• The coffee was the bitterest brew in the café.
• Their divorce was marked by the bitterest arguments.
• She spoke with the bitterest tone about her former friend.
• The bitterest cold of winter finally arrived.
• It was the bitterest defeat of his career.
• The bitterest irony was that he lost everything trying to save it.