1. to leave a place, especially to start a journey
2. to change from an established course or method

Examples

• The train will depart from platform 3 at 9:15 AM.
• We need to depart early to avoid traffic.
• The guests began to depart after midnight.
• She decided to depart from her usual routine.
• The new policy departs significantly from previous guidelines.
• Flight 247 is scheduled to depart in twenty minutes.
• He departed from the script during his speech.