1. to put (a musical instrument) out of tune; to adjust away from the correct pitch
Usage: third person singular present tense of 'detune'
2. to reduce or diminish the effectiveness, sensitivity, or responsiveness of something
Usage: figurative or technical use

Examples

• The guitarist detunes his strings before storing the instrument for winter.
• Excessive noise detunes the listener's ability to concentrate.
• The medication detunes the patient's immune response to prevent rejection.
• She accidentally detunes the piano when moving it across the room.
• Environmental stress detunes the ecosystem's natural balance.
• The engineer detunes the engine to reduce emissions.