1. superlative form of drool; most inclined to drool or characterized by excessive saliva flowing from the mouth
Usage: informal; often used to describe babies, animals, or people in certain states
2. superlative form of drool; most foolish or stupid (informal/slang usage)
Usage: informal; slang; less common

Examples

• The drooliest puppy in the litter was always the most playful.
• My baby nephew is at his drooliest stage right now, teething constantly.
• That was the drooliest joke I've ever heard—it made no sense at all.
• The dog looked drooliest after running around the park all afternoon.
• He gave the drooliest grin when he saw the birthday cake.