dysphoria

noun
  1. a state of unease, dissatisfaction, or unhappiness; a feeling of emotional distress or discomfort.
  2. Usage: commonly used in psychology and medicine; often contrasted with euphoria
  3. persistent discomfort with one's assigned sex or gender identity; a clinical condition characterized by distress arising from a mismatch between one's gender identity and assigned sex at birth.
  4. Usage: medical/clinical term; recognized in DSM-5 and ICD-11

Examples