noun
- a complete, catalytically active enzyme consisting of an apoenzyme combined with its cofactor or coenzyme
Usage: biochemistry
Examples
- The holoenzyme requires both the protein component and the metal cofactor to function properly.
- Without the coenzyme, the apoenzyme cannot form the active holoenzyme.
- Researchers studied the holoenzyme’s structure to understand its catalytic mechanism.
- The holoenzyme showed maximum activity when all cofactors were present.
- Assembly of the holoenzyme occurs when the apoenzyme binds to its prosthetic group.
- The holoenzyme complex is essential for the metabolic pathway to proceed.