1. relating to or denoting a mutation or allele that produces a reduced or weakened version of the normal gene product, resulting in a partial loss of function.
Usage: genetics; technical

Examples

• The hypomorphic allele reduced enzyme activity to about 30% of normal levels.
• Researchers identified a hypomorphic mutation that caused a mild phenotype in the model organism.
• Unlike null mutations, hypomorphic variants allow some residual protein function.
• The hypomorphic gene produced a truncated protein with partial activity.
• This hypomorphic condition demonstrates incomplete loss of function.