1. delivering the main speech at a conference or event
Usage: present participle of keynote
2. setting the central theme or tone for something
Usage: present participle of keynote

Examples

• She is keynoting the technology conference next week.
• The CEO will be keynoting our annual meeting.
• He spent months preparing for keynoting the summit.
• The professor is keynoting three different events this month.
• Her speech is keynoting the importance of innovation.
• The campaign is keynoting unity as its central message.