1. Plural of loco; a plant of the pea family that causes poisoning in livestock.
Usage: chiefly North American; also called locoweed
2. Plural of loco; a person who is crazy or mentally unstable.
Usage: informal; slang

1. Third-person singular present tense of loco; to make crazy or cause to behave irrationally.
Usage: informal; usually used with 'out'

Examples

• The rancher warned that locoes growing in the pasture could poison the cattle.
• Several locoes were admitted to the psychiatric ward that evening.
• The constant noise from construction locoes him out every morning.
• Horses that eat locoweed can become unpredictable and dangerous.
• He's been acting like a loco ever since he lost his job.
• The stress of the deadline is starting to loco her out.