1. the quality or state of being malignant; extreme malevolence or spite
2. the tendency of a medical condition to become progressively worse and potentially life-threatening
Usage: medical

Examples

• The malignance in his voice was unmistakable as he delivered the threat.
• Her actions were driven by pure malignance toward her former colleagues.
• The doctor was concerned about the malignance of the rapidly spreading infection.
• There was a cold malignance in the way he plotted his revenge.
• The tumor’s malignance required immediate and aggressive treatment.
• His malignance toward the community became evident through his destructive behavior.