1. A rare blood disorder characterized by the replacement of bone marrow with fibrous tissue, leading to abnormal blood cell production and enlargement of the spleen.
Usage: medical term; also called myeloid metaplasia or agnogenic myeloid metaplasia; one of the myeloproliferative neoplasms

Examples

• The patient was diagnosed with myelofibrosis after blood tests revealed abnormal cell counts.
• Myelofibrosis can cause severe anemia and fatigue in affected individuals.
• Treatment options for myelofibrosis include medications to manage symptoms and reduce spleen enlargement.
• The doctor explained that myelofibrosis develops when bone marrow is progressively replaced by scar tissue.
• Patients with myelofibrosis often experience an enlarged spleen, a condition called splenomegaly.