1. most irritating, annoying, or vexing; most likely to provoke anger or impatience
Usage: superlative form of nettle (adjective)
2. most prickly or covered with nettles (the plant); most resembling nettles
Usage: literal sense; less common

Examples

• The nettliest part of the negotiation was deciding how to split the profits.
• His nettliest habit was interrupting people mid-sentence.
• That was the nettliest question the interviewer asked all day.
• The nettliest issue facing the committee remained unresolved.
• She found his constant criticism to be the nettliest aspect of working with him.
• The nettliest weeds in the garden were impossible to pull out by hand.