1. in baseball, a play in which a runner is put out while off base, typically by a quick throw from the pitcher or catcher
Usage: baseball
2. the act of intercepting a pass in football
Usage: football
3. the act of shooting or eliminating someone, especially an enemy soldier
Usage: military; informal

Examples

• The pitcher caught the runner with a perfect pickoff to first base.
• The catcher’s quick pickoff attempt ended the inning.
• The quarterback threw three interceptions, including a pickoff in the end zone.
• The defensive back made an easy pickoff when the pass was overthrown.
• The sniper was positioned for a clean pickoff of the enemy target.
• Security forces planned a pickoff operation against the insurgents.