1. in a deep or intense manner; to a great degree
2. in a way that shows deep knowledge or understanding

Examples

• The loss of her father profoundly affected her life.
• He was profoundly grateful for their help during the crisis.
• The new technology will profoundly change how we work.
• She spoke profoundly about the meaning of friendship.
• The earthquake profoundly altered the landscape of the region.
• His words profoundly moved the audience to tears.
• The discovery profoundly challenged existing scientific theories.