1. in a way that is important or notable; to a large or meaningful degree
2. in a way that has special meaning or importance

Examples

• Test scores improved significantly after the new teaching method was introduced.
• The price of gas has risen significantly this year.
• She nodded significantly, indicating she understood the secret message.
• The new medication significantly reduced his symptoms.
• Sales dropped significantly during the recession.
• He looked at her significantly before leaving the room.
• The company’s profits increased significantly last quarter.