1. to make someone unable to think clearly or feel properly; to shock or surprise someone so much that they cannot react
2. to make someone unconscious or less conscious, especially with drugs or alcohol

Examples

• The magician’s trick stupefied the entire audience.
• The news of her sudden resignation stupefied her colleagues.
• The medication will stupefy the patient before surgery.
• He was stupefied by the complexity of the math problem.
• The alcohol had stupefied him to the point where he couldn’t walk straight.
• The stunning revelation stupefied everyone in the courtroom.
• The anesthetic was designed to stupefy the patient during the procedure.